PEPTIC ULCER

hey guys...just wana share with u briefly how peptic ulcer occurs..



ur stomach is lined by many types of cells..eg

chief cell-secrete pepsinogen(proenzyme for protein digestion),

parietal cell-secrete hydrocloric acid, intrinsic factor for absorbtion vitB12

G-cell- gastrin(hormone)

D-cell- somatostatin(hormone)



secretions from all these cells are important for digestion system..pepsinogen will become active in the presence of HCl,then will breakdown protein into small peptide..n blaa blaa blaa...hheeheh but how this cell prevent itself from being digested by its own secretion?(autodigestion)

soo actually, there is "mucosal barrier" presence on the surface of mucosal cell..
mucosal barier is formed by 1.mucus 2.bicarbonate ion that is secreted by mucus neck cell...
function of this mucosal barier is to protect cells lining the stomach from being autodigested...

causes of peptic ulcer:
1. Helicobater pylori-bacteria that cause inflamation of lining of stomach that damage protective mucus layer
2.ASPIRIN and NSAIDs- will inhibit production of prostaglandins(hormone)



one of the various functions of prostaglandins is to
1.decrease(inhibit) gastric(HCl) secretion
2. increase stomach mucus secretion


intake of aspirin n NSAIDs as mention,will decrease prostaglandins secretion,
so there will be increase in HCl n decrease stomach mucus secretion...HCl then will act on cells lining the stomach(that are no longer protected)n leads 2 peptic ulcer...


**NSAIDs- nonsteroidal anti inflammatory drugs
NSAIDs -are widely use to combat pain n treat athritis...

jeng2 sbb 2 laa mummy akn dpt gastric pain biler mkn aspirin o athritis pill..